嵌合胚胎mosaic中可能存在自我矯正機制，嵌合胚胎有可能發育成正常胚胎。

 大多數減數分裂衍生的非整倍體出現在卵子發生過程中。

40歲以上女性產生的卵母細胞中超過50%被證明是染色體異常。

有生育能力的男性精子中染色體異常的發生率在 3% 到 5% 之間。

準確診斷胚胎異常的機率為100%，而整倍體胚胎被分類為臨床適當的比例為61.9%。

J Assist Reprod Genet 2024 May;41(5):1127-1141.   

Hum Reprod. 2019 Apr 1;34(4):758-769.

• There may be a self-correcting mechanism in mosaic embryos, which allows some mosaicisms to potentially develop into normal embryos. 
•  Majority of meiotically derived aneuploidies arise during oogenesis. 
• more than 50 % of oocytes generated by women over the age of 40 years were demonstrated to be chromosomally abnormal. 
• The incidence of chromosome anomalies ranged between 3 and 5 % in the sperm of fertile men. 
• The probability of accurately diagnosing an embryo as abnormal was 100%, while the proportion of euploid embryos classified as clinically suitable was 61.9%. 

Figure 2

Blastocyst chromosomal profiles related to culture outcomes. Euploid blastocysts and those presenting with chromosomal gains and mosaicism were significantly more likely to remain viable 12 days post-fertilisation (dpf), compared to blastocysts with chromosomal losses or multiple aberrations.